The antibodies produced by our immune system, that is to say the system responsible for the defense of our body, allow us to fight multiple infections against microbes such as viruses and bacteria. However, in the case of certain autoimmune diseases such as type 1 diabetes, individuals produce antibodies against the pancreas even before the onset of the disease. Thus attacked, the pancreas can no longer secrete the insulin necessary to regulate blood sugar. The conclusion of work carried out by researcher Sylvie Lesage, Ph.D., whose results have just been published in the Journal of Immunology, could lead to the identification of genes promoting the production of antibodies against the elements susceptible cause type 1 diabetes.
As in humans, mice predisposed to type 1 diabetes produce large amounts of antibodies against the pancreas. By studying these mice predisposed to type 1 diabetes, the researchers were able to establish a link between genetics, type 1 diabetes and the production of antibodies. In addition, as part of this study, Dr. Lesage's laboratory team created a type of mouse with genes resistant to type 1 diabetes. These mice produce fewer antibodies and do not develop diabetes. Their continued research will help to learn more about these links between genes, antibodies and type 1 diabetes.