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Sylvie Lesage

Lesage, Sylvie

Scientific Director and Full professor

Affiliation

Université de Montréal

Research Axes

Immunology-oncology

Contact information

Phone: 514-252-3400, poste 4649

sylvie.lesage@umontreal.ca

Team

  • Adrien Fois
  • Capucine Bourel
  • Daria Vdovenko, PhD
  • Ernesto Fajardo
  • Félix Lombard-Vadnais, PhD
  • Geneviève Chabot-Roy
  • Joëlle Plourde
  • Laurence Caron
  • Lise Coderre, PhD
  • Sahily Rodriguez Torres
  • Sarah Pasquin, PhD

Sylvie Lesage holds a doctorate in immunology, is the scientific director of the Centre de recherche de l'Hôpital Maisonneuve-Rosemont and heads the Cellular Immunogenetics Research Unit.. She is also a full professor in the Department of Microbiology, Infectious Diseases and Immunology at Université de Montréal.

While peripheral T lymphocyte tolerance has shown to significantly contribute to a predisposition to autoimmune diseases, Sylvie Lesage has found that central tolerance plays a major role as well. The goal of her research team is to define the biology and genetics of the cell populations of the immune system that help induce immune tolerance and thus prevent autoimmune diseases.

Research Unit

Cellular Immunogenetics

Our goal is to measure the homeostatic significance of different immune system cell populations to identify each one's impact on the predisposition to complex genetic diseases, such as autoimmune diseases and cancer.

Research interests

This unit also studies:

  • Variations in subpopulations of T lymphocytes, natural killer cells and dendritic cells in various mouse lines.
  • The understanding of the dynamics of immune system cell populations.
  • The impact of genetic mutations that cause monogenic diseases, such as lactic acidosis and Li-Fraumeni syndrome, on immune system homeostasis.

These studies will serve as a springboard for translational research to restore immune balance and prevent the onset or slow the progression of various autoimmune diseases and lymphoid cancers. To achieve these goals, we use a variety of technologies: transgenic and congenic mice, cell immunology, multiparameter flow cytometry, and genetic polymorphism analysis.

  • Félix Lombard-Vadnais, Roxanne Collin, Jean-François Daudelin, Geneviève Chabot-Roy, Nathalie Labrecque, Sylvie Lesage. The Idd2 locus confers prominent resistance to autoimmune diabetes. 2022, Journal of Immunology (Top Read), ji2100456; DOI: doi.org/10.4049/jimmunol.2100456
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  • Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco Jose Naranjo-Galindo, Felix Lombard-Vadnais, Steffie Junius, David Bending, Tino Hochepied, Timotheus Y.F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, and Adrian Liston. Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits. 2022, Journal of Experimental Medicine, 219 (7): e20212391. DOI: doi.org/10.1084/jem.20212391
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  • Roxanne Collin, Félix Lombard-Vadnais, Erin E. Hillhouse, Marie-Ève Lebel, Geneviève Chabot-Roy, Heather J. Melichar, Sylvie Lesage. MHC-independent thymic selection of CD4 and CD8 co-receptor negative αβ T cells. 2020, Journal of Immunology, 205(1):133-142. DOI: 10.4049/jimmunol.2000156
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  • Anne-Marie Aubin, Félix Lombard-Vadnais, Roxanne Collin, Holly A. Aliesky, Sandra M. McLachlan and Sylvie Lesage. The NOD Mouse Beyond Autoimmune Diabetes. 2022, Frontiers in Immunology, 29;13:874769. DOI: 10.3389/fimmu.2022.874769
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  • Roxanne Collin, Lois Balmer, Grant Morahan, Sylvie Lesage. Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross. 2019, Journal of Immunology, 202(3):777-786. DOI: 10.4049/jimmunol.1801247
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Education

  • Senior postdoctoral fellowship

    Université de Montréal

  • Postdoctoral fellowship

    Australian National University

  • PhD in immunology

    McGill University

  • BSc in immunology

    McGill University

Awards

  • 2019 Research Scholar Emeritus  (FRQS)
  • 2015 Senior Research Scholar  (FRQS)
  • 2010 New Investigator Award  (CIHR)
  • 2007 Junior 1 Research scholar  (FRQS)
  • 2002 Career development grant  (CIHR)
  • 1999 Postdoctoral fellowship award  (IRSC)
  • 1995 Graduate award  (FRQS)