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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Silvy Lachance

Silvy Lachance

Full professor


Université de Montréal

Research Axes

Clinical research

Contact information

Dr. Lachance was the Medical and Administrative Director of the Hematopoietic Stem Cell Transplantation Program at Hôpital Maisonneuve-Rosemont (HMR) from 2008 to 2020. A clinical researcher in hematology, transplantation and cell therapy, she developed and launched the transplantation and cell therapy fellowship program at Université de Montréal in 2008 and led the project to have the Royal College of Physicians and Surgeons of Canada recognize hematopoietic cell transplantation as a hematology subspecialty. She is a full professor of medicine at Université de Montréal, and her communication skills make her a popular teacher and guest speaker. Since 2016, she has directed the university program in adult hematology at Université de Montréal.

Research Unit

Dr. Lachance’s interests include not only hematopoietic stem cell transplantation and cell therapy but also the improvement and management of post-transplant complications; the pathophysiology, prevention and treatment of graft-versus-host disease (GVHD); the understanding of the graft-versus-tumour effect; and treatments for hematologic malignancies.

  • Denis-Claude Roy, Silvy Lachance, Sandra Cohen, Jean-Sébastien Delisle, Thomas Kiss, Guy Sauvageau, Lambert Busque, Imran Ahmad, Lea Bernard, Nadia Bambace, Radia S Boumé-dine, Marie-Claude Guertin, Katayoun Rezvani, Stephan Mielke, Claude Perreault, Jean Roy. Allodepleted T-cell Immunotherapy After Haploidentical Haematopoietic Stem Cell Transplanta-tion Without Severe Acute Graft-Versus-Host Disease (GVHD) in the Absence of GVHD Prophylaxis. British Journal Hematology, 186, (5), 754-766, Sept 2019. PMID 311335970
  • Sandra Cohen, Jean Roy, Silvy Lachance, Jean-Sébastien Delisle, Anne Marinier, Lambert Busque, Denis-Claude Roy, Frédéric Barabé, Imran Ahmad, Nadia Bambace, Léa Bernard, Thomas Kiss, Philippe Bouchard, Pierre Caudrelier, Sévérine Landais, Fannie Larochelle, Jalila Chagraoui, Bernhard Lehnertz, Sophie Corneau, Elisa Tomellini, Jeroen J.A. van Kampen, Jan J. Cornelissen, Maude Dumont-Lagacé, Mégane Tanguay, Qi Li, Sébastien Lemieux, Peter W. Zandstra, Guy Sauvageau. Hematopoietic Stem Cell Transplantation using single UM171-expanded cord blood: a single arn, Phase 1-2 safety and feasability study. Lancet Hematology, 7, (2), e134-e145, Feb 2020. PMID: 31704264
  • Denis-Claude Roy, Irwin Walker, Johan Maertens, Philippe Lewalle, Eduardo Olavarria, Domink Selleslag, Silvy Lachance, Marc Buyse, Kun Wang, Jeroen Rovers, Irene Santi, Halvag Bonig, Andrew Sandler, Jurjen Velthuis, Stephan Mielke. ATIR101 administered after T-cell-depleted Haploidentical HSCT reduces NRM and improves overall survival in acute leukemia. Leukemia 2020 Feb 11. PMID: 32047237
  • Routy B, Letendre C, Enota D, Chénard-Poirier M, Mehraj V, Charbonneau Séguin N, Guenda K, Gagnon K, Woerther PL, Gheza D, Lachance S. The influence of gut-decontamination prophylactic antibiotics on acute graft-versus-host disease and survival following allogeneic hematopoietic stem cell transplantation. Oncoimmunology. Dec 27 ; 6(1) : 2016. PMID : 28197380


  • Doctor of Medicine

    Université de Sherbrooke

  • Licence of the Medical Council of Canada

  • Fellow of the Royal College of Physicians and Surgeons of Canada in internal medicine

  • Fellow of the Royal College of Physicians and Surgeons of Canada in hematology

  • Advanced diploma in immunology

    Pasteur Institute

  • Fellowship in biological and clinical bone marrow transplantation

    Hôpital Henri Mondor

  • Laboratory research on the in-vitro prediction of acute graft-versus-host disease and graft response

  • CLIME (Canadian Leadership Institute for Medical Education)

  • U-LEAD (Leadership in Medical Teaching)


  • 2017 2nd prize: Best oral presentation  (AMHOQ Conference)
  • 2017 1st prize: Best oral presentation  (AMHOQ Conference)
  • 2017 Article of the year  (American Journal of Epidemiology)
  • 2014 IMS/Brogan award
  • 2012 Excellence in teaching award  (Université de Montréal)
  • 2012 2012 vice-rector’s award for pedagogical innovation  (Université de Montréal)