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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Przemyslaw (Mike) Sapieha

Sapieha, Przemyslaw (Mike)

Full professor

Affiliation

Université de Montréal

Research Axes

Vision health

Contact information

Phone: 514-252-3400, poste7711

mike.sapieha@umontreal.ca

sapiehalab.com

Team

  • Agnieszka Dejda
  • Ariel Wilson
  • Vera Guber
  • Guillaume Blot
  • Yusuke Ichiyama
  • Anne Wolf
  • Roberto Diaz Marin
  • Frédérik Fournier
  • Jeffery Sullivan
  • Gabrielle Girouard
  • Frédérique Pilon
  • Michelle Barbagallo
  • Cara Haway
  • Jules Barthelemy
  • Normand Beaulieu

With a PhD in neuroscience, Przemyslaw (Mike) Sapieha is the director of the Neurovascular Eye Disease Research Unit at Hôpital Maisonneuve-Rosemont. Using the eye as a model, his lab studies angiogenesis and the factors that control it. Specifically, he studies the cellular interactions and intracellular mechanisms that govern vascular growth in both physiological and pathological contexts.

The Canada Research Chair in Retinal Cell Biology and holder of the Wolfe Professorship in Translational Vision Research, Mike Sapieha is also an associate professor in the Department of Ophthalmology and an adjunct professor in the Department of Biochemistry and Molecular Medicine at Université de Montréal.

Research Unit

Neurovascular Eye Disease

Research interests

Vasoproliferative eye diseases are the main causes of vision loss in developed countries. For example, diabetic retinopathy and retinopathy of prematurity affects working-age and pediatric populations, while age-related macular degeneration affects older populations. These conditions are characterized by the excessive growth of retinal vessels that can lead to fibrotic scars and possibly retinal detachment. This disproportionate hyper-vascularization is part of a compensatory mechanism that attempts to overcome microvessel degeneration by restoring metabolic balance to the hypoxic retina.

    • Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results Crespo-Garcia S*, Fournier F*, Diaz-Marin R*, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G*, Hafiane I*, Dejda A*, Rizk R, Juneau R*, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M*, Nguyen A, Sullivan L, Damiano J, Wilson AM*, Mallette FA, David NE, Ghosh A, Tsuruda PR*, Dananberg J, Sapieha P * Nature Medicine. February 6th, 2024.
    • Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life Hata M*, Hata M*, Andriessen EM*, Juneau R*, Pilon F*, Crespo-Garcia S*, Diaz-Marin R*, Guber V*, Binet F*, Fournier F*, Buscarlet M, Grou C, Calderon V, Heckel E, Melichar HJ, Joyal JS, Wilson AM*, Sapieha P. J Clin Invest. 2023 Feb 15;133(4):e159757. doi: 10.1172/JCI159757


    • Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation. Hata M*, Andriessen EMMA*, Hata M*, Diaz-Marin R*, Fournier F*, Crespo-Garcia S*, Blot G*, Juneau R*, Pilon F*, Dejda A*, Guber V*, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM*, Sapieha P. Science. 2023 Jan 6;379(6627):45-62. doi: 10.1126/science.abj8894.
    • Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis. Fournier F*, Diaz-Marin R*, Pilon F*, Neault M*, Juneau R*, Girouard G*, Wilson AM*, Larrivée B, Mallette FA, Crespo-Garcia S*, Sapieha P. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2209973120. doi: 10.1073/pnas.2209973120. Epub 2022 Dec 27.PMID: 36574648
    • Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition. Crespo-Garcia S*, Tsuruda PR, Dejda A*, Ryan RD, Fournier F*, Chaney SY, Pilon F, Dogan T, Cagnone G, Patel P, Buscarlet M, Dasgupta S, Girouard G*, Rao SR, Wilson AM*, O'Brien R, Juneau R*, Guber V*, Dubrac A, Beausejour C, Armstrong S, Mallette FA, Yohn CB, Joyal JS, Marquess D, Beltran PJ, Sapieha P. Cell Metab. 2021 Feb 2:S1550-4131(21)00011-5.
    • Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Côté JF, Andelfinger G, Rezende FA, Sennlaub F, Joyal JS, Mallette FA, Sapieha P.
      Science. 2020 Aug 21;369(6506):eaay5356. doi: 10.1126/science.aay5356
    • Notch1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, Oubaha M, Menard C, Dejda A, Joyal JS, Gratton JP, Larrivée B, Sapieha P. P.N.A.S. 2019 Feb 20. pii: 201814711. doi: 10.1073/pnas.1814711116
    • Macrophage-resident Neuropilin-1 safeguards against obesity and metabolic syndrome. A Wilson, Z Shao, V Grenier, G Mawambo, J-F Daudelin, A Dejda, F Pilon, N Popovic, S Boulet, C Parinot, M Oubaha, N Labrecque, V de Guire, M Laplante, G Lettre, F Sennlaub, J-S Joyal, M Meunier, P Sapieha. Science Immunology 2018 Mar 16;3(21). With Editorial in Nature Reviews Immunology
    • Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. Andriessen EM, Wilson AM, Mawambo G, Dejda A, Miloudi K, Sennlaub F, Sapieha P. EMBO Mol Med. 2016 Dec 1;8(12):1366-1379. doi: 10.15252/emmm.201606531.
      More detail
    • Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, Bourdel G, Popovic N, Rezende FA, Kaufman RJ, Mallette FA, Sapieha P .Sci Transl Med. 2016 Oct 26;8(362):362ra144.
      More detail
    • Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. Miloudi K, Binet F, Wilson A, Cerani A, Oubaha M, Menard C, Henriques S, Mawambo G, Dejda A, Nguyen PT, Rezende FA, Bourgault S, Kennedy TE, Sapieha P. J Clin Invest. 2016 Aug 1;126(8):3006-22. doi: 10.1172/JCI84767.
    • ER Stress and Angiogenesis. Binet F & Sapieha P. Cell Metabolism. 2015 Aug 12. pii: S1550-4131(15)00339
    • Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. Dejda A, Mawambo G, Cerani A, Miloudi K, Shao Z, Daudelin JF, Boulet S, Oubaha M, Beaudoin F, Akla N, Henriques S, Menard C, Stahl A, Delisle JS, Rezende FA, Labrecque N, Sapieha P. J Clin Invest. 2014 Nov;124(11):4807-22. doi: 10.1172/JCI76492.
    • Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cerani A, Tetreault N, Menard C, Lapalme E, Patel C, Sitaras N, Beaudoin F, Leboeuf D, De Guire V, Binet F, Dejda A, Rezende FA, Miloudi K, Sapieha P. Cell Metab. 2013 Oct 1;18(4):505-18. doi: 10.1016/j.cmet.2013.09.003.
    • Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE, Sapieha P. Cell Metab. 2013 Mar 5;17(3):353-71. doi: 10.1016/j.cmet.2013.02.003.
    • Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. Blood. 2011 Jun 2;117(22):6024-35. doi: 10.1182/blood-2010-10-311589.

    Education

    • Postdoctoral fellowship in vascular biology

      Harvard Medical School

    • Postdoctoral fellowship in vascular biology

      McGill University

    • PhD in neuroscience

      Université de Montréal

    Awards

    • 2024 Effervescence Star Award
    • 2024 William W. Dawson Memorial Keynote Lecture. International Society for Clinical Electrophysiology of Vision (ISCEV)
    • 2022 FROUM Endowed Chair
    • 2022 Annual Lecture (University College London- department of ophthalmology)
    • 2022 Innovation in AMD Award, Bright Focus Foundation
    • 2021 Canada Research Chair in Retinal Cell Biology (Tier 1)
    • 2020 Alcon Research Institute Senior Investogator Award
    • 2019 Cogan Award  (Association for Research in Vision and Ophthalmology)
    • 2018 Elected member  (College of the Royal Society of Canada)
    • 2017 Joe Doupe Award  (Canadian Society of Clinical Investigation)
    • 2017 Young Investigator Award  (Canadian Association for Neuroscience)
    • 2016 Professorship in Translational Vision Research  (Wolfe )
    • 2015 André-Dupont New Investigator Award  (Club de recherches cliniques du Québec)
    • 2012 Young Investigator Grant  (Alcon Research Institute)
    • 2010 Canada Research Chair in Retinal Cell Biology
    • 2010 Young Investigator Award  (Canadian National Institute for the Blind)
    • 2009 Postdoctoral fellowship  (Charles A King Trust)