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Pascal-André Vendittoli

Vendittoli, Pascal-André

Full professor


Université de Montréal

Research Axes


Contact information

Phone: 514 252-3823


  • Janie Barry
  • Julien Clément
  • Daniel Lusignan
  • Serge Marquis
  • Karina Pellei

Dr. Pascal-André Vendittoli is an orthopedic surgeon and a senior FRQS clinical research scholar in the Joint Reconstruction Research Unit at Hôpital Maisonneuve-Rosemont. He is interested in the evaluation of new technologies in hip and knee reconstruction mainly through prospective and randomized studies. He is also a full professor in the Department of Surgery at Université de Montréal (geographical full-time).

His work has been presented over 300 times at scientific conferences, he has been an invited speaker over 200 times, and he has published over 100 scientific articles in peer-reviewed journals. He has received the orthopedic community's most prestigious awards, such as the John Charnley Award from the Hip Society (US) and the J. Édouard Samson Award from the Canadian Orthopaedic Foundation.

Research Unit

Joint Reconstruction

Joint degeneration is the leading degenerative musculoskeletal disease and affects 1 in 8 Canadians (13%), with the hip and knee being the joints most commonly affected by this condition. Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are the most common orthopedic surgeries in Canada. Despite their high success rate and very positive cost/benefit ratio, 10% to 20% of subjects who undergo THA or TKA have disappointing outcomes.  Since these treatments are very common, improvements in care are warranted and could have a significant impact on population health and costs.

Canada currently has five issues in this area:

  1. Poor identification of individual success and failure factors when selecting candidates for a joint replacement procedure (THA and TKA).
  2. Avoidable perioperative complications related to the surgery (pain control, medical and orthopedic complications).
  3. The implantation of prostheses that do not reproduce joint biomechanics and do not provide natural joint function.
  4. The use of less than optimal surgical techniques (that do not match patient anatomy or that lack precision).
  5.  The use of implants with manufacturing defects or that do not have adequate survival rates (high risk with new technologies since Health Canada does not require a phased introduction for “implants”). 

Our research program aims to improve these issues. The goal of my program is to optimize the management and treatment of patients with knee and hip degeneration. We also want to determine the value and benefits of introducing new techniques and technologies in lower limb reconstruction.

  • Kinematic alignment in total knee arthroplasty better reproduces normal gait than mechanical alignment. Blakeney W, Clément J, Desmeules F, Hagemeister N, Rivière C, Vendittoli PA. Knee Surg Sports Traumatol Arthrosc. 2019 May;27(5):1410-1417. doi: 10.1007/s00167-018-5174-1. Epub 2018 Oct 1.
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  • Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty. Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M, Pelet S, Fisher W, Belzile E, Dolan S, Crowther M, Bohm E, MacDonald SJ, Gofton W, Kim P, Zukor D, Pleasance S, Andreou P, Doucette S, Theriault C, Abianui A, Carrier M, Kovacs MJ, Rodger MA, Coyle D, Wells PS, Vendittoli PA. N Engl J Med. 2018 Feb 22;378(8):699-707. doi: 10.1056/NEJMoa1712746.

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  • The Impact of Mechanical and Restricted Kinematic Alignment on Knee Anatomy in Total Knee Arthroplasty. Almaawi AM, Hutt JRB, Masse V, Lavigne M, Vendittoli PA. J Arthroplasty. 2017 Jul;32(7):2133-2140. doi: 10.1016/j.arth.2017.02.028. Epub 2017 Feb 20.
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  • Comparison of Whole-Blood Metal Ion Levels Among Four Types of Large-Head, Metal-on-Metal Total Hip Arthroplasty Implants: A Concise Follow-up, at Five Years, of a Previous Report. Hutt J, Lavigne M, Lungu E, Belzile E, Morin F, Vendittoli PA. J Bone Joint Surg Am. 2016 Feb 17;98(4):257-66. doi: 10.2106/JBJS.O.00201.
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  • A randomised trial of all-polyethylene and metal-backed tibial components in unicompartmental arthroplasty of the knee. Hutt JR, Farhadnia P, Massé V, LaVigne M, Vendittoli PA. Bone Joint J. 2015 Jun;97-B(6):786-92. doi: 10.1302/0301-620X.97B6.35433.
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  • Metal-on-metal hip resurfacing compared with 28-mm diameter metal-on-metal total hip replacement: a randomised study with six to nine years' follow-up. Vendittoli PA, Rivière C, Roy AG, Barry J, Lusignan D, Lavigne M. Bone Joint J. 2013 Nov;95-B(11):1464-73. doi: 10.1302/0301-620X.95B11.31604.
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  • Alumina on alumina versus metal on conventional polyethylene: a randomized clinical trial with 9 to 15 years follow-up. Vendittoli PA, Rivière C, Lavigne M, Lavoie P, Alghamdi A, Duval N. Acta Orthop Belg. 2013 Apr;79(2):181-90.
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  • Periarticular injection in knee arthroplasty improves quadriceps function. Chaumeron A, Audy D, Drolet P, Lavigne M, Vendittoli PA. Clin Orthop Relat Res. 2013 Jul;471(7):2284-95. doi: 10.1007/s11999-013-2928-4. Epub 2013 Mar 21. Erratum in: Clin Orthop Relat Res. 2013 Jun;471(6):2042.
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  • The John Charnley Award: The functional outcome of hip resurfacing and large-head THA is the same: a randomized, double-blind study. Lavigne M, Therrien M, Nantel J, Roy A, Prince F, Vendittoli PA. Clin Orthop Relat Res. 2010 Feb;468(2):326-36. doi: 10.1007/s11999-009-0938-z. Epub 2009 Jun 20.
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  • A multimodal analgesia protocol for total knee arthroplasty. A randomized, controlled study. Vendittoli PA, Makinen P, Drolet P, Lavigne M, Fallaha M, Guertin MC, Varin F. J Bone Joint Surg Am. 2006 Feb;88(2):282-9.
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  • Diploma of specialized study in orthopedic surgery

    Fellowship of the Royal Colleges of Surgeons


  • 2019 Performance prize (1st place), Stars du réseau de la santé  (Caisse Desjardins de la Santé du Québec)
  • 2018 Paper of the Year Award  (Canadian Hematology Society )
  • 2017 Senior Clinical Research Scholar  (Fond de recherche en Santé du Québec)
  • 2017 Medal  (Société Française de la Hanche et du Genou)
  • 2016 J. Édouard Samson Award (outstanding research career)  (Canadian Orthopaedic Foundation)
  • 2015 Better research partnerships between industry and researchers  (Association pour le développement la recherche et de l’innovation du Québec)
  • 2011 Junior 2 Clinical Research Scholar  (Fond de recherche en Santé du Québec)
  • 2010 Founder’s Medal Award (best fundamental research project)  (Canadian Orthopaedic Foundation)
  • 2009 John Charnley Award (outstanding research in hip joint replacement)  (The Hip Society, USA)
  • 2003 Alexandra Kirkley Award (promising young investigator)  (Canadian Orthopaedic Foundation)