Full professor
Affiliation
Université de Montréal
Research Axes
Team
- Denise Descovich
- Annie Laporte
- Marisse Masis Solano
- Chris Tebid
- Alejandra Martinez
Dr. Mark Lesk is Chief of Ophthalmology at the Centre Universitaire d’Ophtalmologie at HMR and Director of the Glaucoma Research Laboratory at the Centre de Recherche de l'Hôpital Maisonneuve-Rosemont. He is also a full professor in the Department of Ophthalmology at Université de Montréal.
Research Unit
Glaucoma Research Laboratory
Research interests
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Influence of ocular biomechanics and blood flow on the optic nerve in glaucoma and other eye diseases including Spaceflight-Associated Neuro Ocular Syndrome (SANS);
- Development of a new imaging device to measure the biomechanical properties of the eye (patent pending);
- Stem cell regeneration in glaucoma;
- Gene Therapy for Glaucoma.
Grants
- CIHR
- NASA/Canadian Space Agency
- NSERC
- FRQS Vision Health Research Network
- Glaucoma Research Society of Canada
Publications
Voir toutes les publications-
Ocular Biomechanical Responses to Long-Duration Spaceflight. M. M. Solano, R. Dumas, M. R. Lesk and S. Costantino. IEEE Open Journal of Engineering in Medicine and Biology, vol. 6, pp. 127-132, 2025, doi:10.1109/OJEMB.2024.3453049.
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The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity. Sayah DN, Descovich D, Costantino S, Lesk MR. Ophthalmol Sci. 2024 Jul 18;4(6):100576. 2024 Nov-Dec.PMID: 39253552.
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Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study. Masís Solano M, Richer E, Costantino S, Lesk MR. Bioengineering (Basel). 2024 Apr 23;11(5):PMID: 38790278.
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Ocular rigidity and choroidal thickness changes in response to microgravity: A case study. Masís Solano M, Bélanger Nzakimuena C, Dumas R, Lesk MR, Costantino S. Am J Ophthalmol Case Rep. 2023 Oct 7;32:101940. eCollection 2023 Dec.PMID: 37860670.
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Variable phenotypic expression of MYOC mutations in a family with inherited pediatric glaucoma. Mullie GA, Javidi S, Soucy JF, Lesk MR, Hamel P. Can J Ophthalmol. 2023 Dec;58(6):e269-e270. Epub 2023 May 27.PMID: 37247815.
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Ocular Rigidity and Current Therapy. Sayah DN, Lesk MR. Curr Eye Res. 2023 Feb;48(2):105-113. Epub 2022 Jul 6.PMID: 35763027 Review.
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The Association Between Ocular Rigidity and Neuroretinal Damage in Glaucoma. Sayah DN, Mazzaferri J, Descovich D, Costantino S, Lesk MR. Invest Ophthalmol Vis Sci. 2020 Nov. 2;61(13):11. PMID: 33151280.
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Non-invasive in vivo measurement of ocular rigidity: Clinical validation, repeatability and method improvement. Sayah DN, Mazzaferri J, Ghesquière P, Duval R, Rezende F, Costantino S, Lesk MR. Exp Eye Res. 2020 Jan;190:107831. Epub 2019 Oct 10.PMID: 31606450.
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Neuroretinal Rim Area Change in Glaucoma Patients With Visual Field Progression Endpoints and Intraocular Pressure Reduction. The Canadian Glaucoma Study: 4.Malik R, O, Leary N, Mikelberg FS, Balazsi AG, LeBlanc RP, Lesk MR, Nicolela MT, Trope GE, Chauhan BC; Canadian Glaucoma Study Group.Am J Ophthalmol. 2016 Mar;163:140-147. Epub 2015 Dec 17.PMID: 26705093.
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Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment. Manuguerra-Gagné R, Boulos PR, Ammar A, Leblond FA, Krosl G, Pichette V, Lesk MR, Roy DC. Stem Cells. 2013 Jun;31(6):1136-48. PMID: 23495088.
Education
Fellowship (glaucome)
Wills Eye Hospital, Philadelphie
Ophthalmology
Université de Montréal
Doctor of Medicine
McGill University
MSc
Weizmann Institute of Science, Israel