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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Mark Lesk

Lesk, Mark

Full professor


Université de Montréal

Research Axes

Vision health

Contact information

Phone: 514-252-3400, poste4959


  • Denise Descovich
  • Annie Laporte
  • Diane Noël Sayah

Dr. Mark Lesk is an ophthalmologist and researcher in the Pathophysiological Mechanisms of the Eye Research Unit at Hôpital Maisonneuve-Rosemont. He is also an associate professor in the Department of Ophthalmology at Université de Montréal.

Research Unit

Pathophysiological Mechanisms of the Eye

Research interests

  • Influence of blood flow and ocular biomechanics on the optic nerve in glaucoma
  • Development of a new imaging device to measure the biomechanical properties of the optic nerve (patent pending)
  • Stem cell regeneration in glaucoma
  • Blood flow deficiency in AMD


  • FRQS Vision Health Research Network
  • Glaucoma Research Foundation (San Francisco)
  • Hafez A, Bizzarro RLG, Rivard M, Lesk MR. Changes in optic nerve head blood flow after therapeutic intraocular pressure reduction in glaucoma patients and ocular hypertensives. Ophthalmology, 110(1):201-10, 2003.
  • Harasymowycz PJ, Kamdeu Fansi A, Papamatheakis DG, Gresset J, Lesk MR. Validity of screening for glaucomatous optic nerve damage using confocal scanning laser ophthalmoscopy (HRT II) in high risk populations: A Pilot Study. Ophthalmology, 112(12) 2164-2171, 2005.
  • Hafez AS, Bizzarro R, Descovich D, Lesk MR. Correlation between finger blood flow and changes in optic nerve Head Blood Flow following Therapeutic Intraocular Pressure Reduction. J Glaucoma, 14(6) 448-454, 2005.
  • Lesk MR, Hafez, AS., Descovich D. Relationship between Central Corneal Thickness and Changes of Optic Nerve Head Topography and Blood Flow After Intraocular Pressure Reduction in Open-angle Glaucoma and Ocular Hypertension. Arch Ophthalmol, 124 (11): 1568-1572, 2006.
  • B.C. Chauhan , F.S. Mikelberg , A.G. Balaszi , R.P. LeBlanc , M.R. Lesk , G.E. Trope, Canadian Glaucoma Study Group. Canadian Glaucoma Study: 2. risk factors for the progression of open-angle glaucoma. Arch Ophthalmol, Aug;126(8):1138-9,2008.
  • Hafez, A.S. Lesk, M.R. Ocular Techniques used for Measurement of Ocular Blood Flow. In Glaucoma, M. Sherwood R. Hitchings, J. Crowston, Shaarawy, E.(eds) Chapter 14, Elsevier Press, 2010.
  • Deschênes MC, Descovich D, Moreau M, Granger L, Kuchel GA, Mikkola TS, Fick GH, Chemtob S, Vaucher E, Lesk MR. Postmenopausal Hormone Therapy Increases Retinal Blood Flow and Protects the Retinal Nerve Fiber Layer. Invest Ophthalmol Vis Sci. 2010 May;51(5):2587-600.
  • Fontaine O, Olivier S, Descovich D, Cordahi G, Vaucher E, Lesk MR. The Effect of Intravitreal Injection of Bevacizumab on Retinal Circulation in Patients with Neovascular Macular Degeneration. Invest Ophthalmol Vis Sci. 2011 Sep 22;52(10):7400-5.
  • Singh K, Dion C, Costantino S, Wajszilber M, Lesk MR, Ozaki T. Development of a novel instrument to measure the pulsatile movement of ocular tissues. Exp Eye Res. 2010 Jul;91(1):63-8.
  • Balwantray C. Chauhan Ph.D., Frederick S. Mikelberg, M.D., Paul H. Artes, Ph.D., A. Gordon Balazsi, M.D., Raymond P. LeBlanc, C.M., M.D., Mark R. Lesk, M.Sc., M.D., Marcelo T. Nicolela, M.D., Graham E. Trope, M.B., Ph.D.; for the Canadian Glaucoma Study Group. The Canadian Glaucoma Study: 3. Impact of Risk Factors and Intraocular Pressure Reduction on the Rates of Visual Field Change. Arch Ophthalmol. 2010 Oct;128(10):1249-55.


  • Fellowship (glaucome)

    Wills Eye Hospital, Philadelphie

  • Ophthalmology

    Université de Montréal

  • Doctor of Medicine

    McGill University

  • MSc

    Weizmann Institute of Science, Israel