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Louis-Philippe Laurin

Laurin, Louis-Philippe

Clinical Associate Professor of Medicine

Affiliation

Université de Montréal

Research Axes

Nephrology

Contact information

lplaurin.hmr@ssss.gouv.qc.ca

Team

  • Mukelda Mikye Castor
  • Karine Chaussé
  • Monica Joseph-Lemieux
  • Sonia Nardo

In addition to his clinical activities as a nephrologist with the CIUSSS de l’Est-de-l’Île-de-Montréal and the Montreal Heart Institute, Dr. Laurin directs a clinic that specializes in glomerular diseases at Hôpital Maisonneuve-Rosemont.

Research Unit

Glomerulonephropathies encompass a group of diseases affecting the glomerulus, which constitutes the filter of the kidney. They constitute the cause of end-stage kidney disease in a significant proportion of individuals on dialysis therapy. Glomerular diseases represent heavy and prolonged individual and societal burden as they usually affect younger individuals and are characterized by progression to end-stage kidney disease over a course of several years. Although common in aggregates, they are considered as rare diseases when taken individually. This heterogeneity and delay in attaining kidney failure has impeded the development of novel therapies through clinical studies. Thus, the establishment of a large cohort of patients with glomerular diseases will fuel research in this field of medicine.

Dr. Laurin’s research program consists in studying the epidemiology of glomerulonephropathies. In 2015, his research unit set up a local registry of patients with glomerular diseases. This cohort of patients serves as a platform for local and international projects.

  • Leclerc S, Benkirane K, Nadeau-Fredette AC, Elftouh N, Lafrance JP, Pichette V, Royal V, Lamarche C, Laurin LP. Qualitative and Quantitative Dosage of the Anti M-Type Phospholipase A2 Receptor Antoantibody: One-Year Experience in Quebec’s Reference Center. Can J Kidney Health Dis. 2021 Oct 26; 8:20543581211052729
  • Leclerc S, Nadeau-Fredette AC, Elftouh N, Lafrance JP, Pichette V, Laurin LP. Use of desmopressin prior to kidney biopsy in patients with high bleeding risk. Kidney Int Rep. 2020 May 20;5(8):1180-1187.
  • O'Shaughnessy MM, Troost JP, Bomback AS, Hladunewich MA, Ashoor IF, Gibson KL, Bou Matar R, Selewski DT, Srivastava T, Rheault MN, Al-Uzri A, Kogon AJ, Khalid M, Vento S, Sanghani NS, Gillespie BW, Gipson DS, Wang C, Parsa A, Guay-Woodford L, Laurin LP. Treatment patterns among adults and children with membranous nephropathy in the Cure Glomerulopathy Network (CureGN). Kidney Int Rep. 2019: 4, 1725-1734
  • Laurin LP, Nachman PH, Foster BJ. Calcineurin Inhibitors in the Treatment of Primary Focal Segmental Glomerulosclerosis: A Systematic Review and Meta-analysis of the Literature. Can J Kidney Health Dis. 2017 Feb 22;4.
  • Laurin LP, Gasim AM, Derebail VK, McGregor JA, Kidd JM, Hogan SL, Poulton CJ, Detwiler RK, Jennette JC, Falk RJ, Nachman PH. Renal survival in patients with collapsing compared with not otherwise specified FSGS. Clin J Am Soc Nephrol. 2016 Oct 7;11(10):1752-1759.
  • Laurin LP, Gasim AM, Poulton CJ, Hogan SL, Jennette JC, Falk RJ, Foster BJ, Nachman PH. Treatment with glucocorticoids or calcineurin inhibitors in primary focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2016: Mar 7;11(3):386-94.
  • Laurin LP, Lu M, Mottl AK, Blyth ER, Poulton CJ, Weck KE. Podocyte-associated gene mutation screening in a heterogeneous cohort of patients with sporadic focal segmental glomerulosclerosis. Nephrol Dial Transplant. 2014 Nov;29(11):2062-9.
  • Laurin LP, Nachman PH, Desai PC, Ataga KI, Derebail VK. Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease. Nephrol Dial Transplant. 2014 Jun;29(6):1211-8.

Education

  • Doctor of Medicine

    Université de Montréal

  • Internal medicine

    Royal College of Physicians and Surgeons of Canada

  • Nephrology

    Royal College of Physicians and Surgeons of Canada

  • Postdoctoral fellowship in glomerular diseases and vasculitis

    University of North Carolina at Chapel Hill

  • MSc in epidemiology

    McGill University

Awards

  • 2021 Clinical Research Scholar – Junior 2  (Fonds de recherche du Québec - Santé)
  • 2020 Young nephrologist of the year  (Société québécoise de néphrologie)
  • 2017 Clinical Research Scholar - Junior 1  (Partenariat FRQS – Société québécoise de néphrologie)
  • 2011 Complementary training award  (Faculty of Medicine of Université de Montréal)