Full professor
Affiliation
Université de Montréal
Research Axes
Contact information
Phone: 514-252-3400, poste4662
Team
- Amira Othman
- Meriem Sekheri
Dr. Janos G. Filep (MD, PhD) heads the Innate Immunology and Vascular Immunology Research Unit. He is also a full professor in the Department of Pathology and Cellular Biology at Université de Montréal.
His extensive expertise covers vascular immunology/inflammation (with a focus on leukocyte and endothelial cell pathophysiology), the regulation of the activation of anti-inflammatory cells, and cardiovascular disease. His research is recognized for contributing to the concept of active inflammation resolution and for identifying the mediators, mechanisms and control points that govern this process.
Research Unit
Innate Immunology and Vascular Immunology
Research interests
- Vascular immunology, inflammation
- Leukocytes and biology of the endothelial cell
- Interactions between leukocytes and endothelial cells
- Oxidative and peroxidative stress (peroxynitrite) and signalling
- Endogenous anti-inflammatory molecules (aspirin-triggered lipoxins, antiflammins, annexin-1, etc.)
- Apoptosis
- Toll-like receptor signalling
- Cardiovascular disease (coronary artery disease, septic shock)
- Diabetic nephropathy
Publications
Voir toutes les publications-
Zouki C, Beauchamp M, Baron C, Filep JG. Prevention of in vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein. J. Clin. Invest. 100:522-529, 1997.
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József L, Zouki C, Petasis NA, Serhan CN, Filep JG. Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc. Natl. Acad. Sci. USA, 99:13266-13271, 2002.
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Khreiss T, József L, Potempa LA, Filep JG. Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells. Circulation 109:2016-2022, 2004.
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Khreiss T, József L, Potempa LA, Filep JG. Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils. Circ. Res., 97:690-697, 2005.
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El Kebir D, József L, Pan W, Filep JG. Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation. Circ Res 103:352-359, 2008.
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El Kebir D, József L, Pan W, Wang L, Petasis NA, Serhan CN, Filep JG. 15-epi-lipoxin A4 inhibits myeloperoxidase signalling and enhances resolution of acute lung injury. Am J Respir Crit Care Med 180:311-319, 2009.
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El Kebir D, Gjorstrup P, Filep JG. Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation. Proc Natl Acad Sci USA 109:14983-14988, 2012.
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Filep JG. Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution. Proc Natl Acad Sci USA 110:18033-18034, 2013.
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El Kebir D, Damlaj A, Makhezer N, Filep JG. Toll-like receptor 9 signaling regulates tissue factor and tissue factor pathway inhibitor expression in human endothelial cells and coagulation in mice. Crit Care Med 43:e179-e189, 2015.
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El Kebir D, de Oliveira Lima dos Santos E, Mansouri S, Sekheri M, Filep JG. Mild acidosis delays neutrophil apoptosis via multiple signaling pathways and acts in concert with inflammatory mediators. J Leukoc Biol, 102:1289-1400, 2017.
Education
Postdoctoral fellowship in immunology
Université de Montréal
Postdoctoral fellowship in pharmacology
Université de Sherbrooke
Postdoctoral fellowship in pharmacology
Medizinische Hochschule Hannover, FRG
Research fellow in pharmacology and clinical pharmacology
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
Research fellow in physiology
Semmelweis University Medical School
Isotope medicine
Postgraduate medical studies, Budapest
Blood Transfusion Medicine
Postgraduate Medical School, Budapest
Doctor of Medicine
Semmelweis University Medical School
MSc (equivalent) in physiology
Semmelweis University Medical School
Awards
- 2010 Member of the Scientific Steering Committee (International Academy of Cardiology)
- 2010 Gold Medal for Canada (American Biographical Institute)
- 2007 Member, Scientific Committee (International Academy of Cardiology, USA)
- 2009 Recognition (Presidential Who's Who, Long Island City, NY)
- 2004 Recognized as one of the “2000 outstanding intellectuals of the 21st Century” (International Biographical Centre, Cambridge)
- 2004 Recognized as one of the “Great minds of the 21st Century” in (American Biographical Institute)
- 2003 Medal for Science and Peace (Albert Schweitzer International University, Genève)
- 2000 Honorary professor (Albert Schweitzer International University, Genève)
- 1993 Senior 2 Research Scholar (FRSQ)
- 1989 Postdoctoral fellowship (Medical Research Council of Canada)