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Guy Sauvageau

Guy Sauvageau

Full Professor

Affiliation

Université de Montréal

Research Axes

Clinical research

Contact information

guy.sauvageau@umontreal.ca

The founding Scientific Director of the Institute for Research in Immunology and Cancer (IRIC), Dr. Guy Sauvageau is also the Canada Research Chair in the Molecular Genetics of Stem Cells and has received many awards and honours, including being named a Fellow of the Royal Society of Canada. Over the past 25 years, his work has led to major breakthroughs in our understanding of the production of normal and leukemic blood stem cells.

Research Unit

Dr. Guy Sauvageau is a member of the Hematopoietic Stem Cell Transplant Clinical Research Unit. He is particularly interested in the molecular genetics of normal and leukemic hematopoietic stem cells. His research team uses modern genetic approaches and closely collaborates with a medicinal chemistry team led by Dr. Anne Marinier at the IRIC. Dr. Sauvageau’s team is actively working to translate its basic research to clinical applications.

  • Chagraoui J1, Girard S1, Spinella JF1, Simon L1, Bonneil E2, Mayotte N1, MacRae T1, Coulombe-Huntington J3, Bertomeu T3, Moison C1, Tomellini E1, Thibault P2, Mike Tyers3, Marinier A4, Sauvageau G1,5,6,7. UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3-KBTBD4 complex. Cell Stem Cell, in press (Jan 7 2021).
  • Dumont-Lagacé M, Li Q, Tanguay M, Chagraoui J, Kientega T, Cardin GB, Brasey A, Trofimov A, Carli C, Ahmad I, Bambace NM, Bernard L, Kiss TL, Roy J, Roy DC, Lemieux S, Perreault C, Rodier F, Dufresne SF, Busque L, Lachance S, Sauvageau G, Cohen S, Delisle JS. UM171-expanded cord blood transplants support robust T cell reconstitution with low rates of severe infections. Biol Blood Marrow Transplant. 2020 Oct 3:S1083-8791(20)30624-8. doi: 10.1016/j.bbmt.2020.09.031. PMID: 33022376.
  • LeBlanc R, Claveau JS, Ahmad I, Delisle JS, Bambace N, Bernard L, Cohen S, Kiss T, Lachance S, Landais S, Roy DC, Sauvageau G, Roy J. Newly diagnosed multiple myeloma patients treated with tandem auto-allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only. Clin Transplant. 2020 Sep 27:e14099. doi: 10.1111/ctr.14099. PMID: 32981146.
  • Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G. Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study. Lancet Haematol. 2020 Feb;7(2):e134-e145. doi: 10.1016/S2352-3026(19)30202-9. Epub 2019 Nov 6.

Education

  • Doctor of Medicine

    Université de Montréal

  • MSc in immunovirology

    Université de Montréal

  • PhD in experimental medicine

    University of British Columbia

  • Specialties in internal medicine and hematology

Awards

  • 2019 Fellow of the Royal Society of Canada
  • 2018 Fellow of the Canadian Academy of Health Sciences
  • 2015 Scientist of the year, 2014  (Radio-Canada)
  • 2015 Scientific personality of the year, 2014  (La Presse)
  • 2015 Léo-Pariseau Award  (Association francophone pour le savoir (Acfas))