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Elliot Drobetsky

Drobetsky, Elliot

Full professor

Affiliation

Université de Montréal

Research Axes

Immunology-oncology

Contact information

Phone: 514-252-3400, poste4665

elliot.drobetsky@umontreal.ca

Team

  • François Bélanger
  • Jiana Li
  • Émile Fortier
  • Jean-François Lemay
  • Mathieu Neault
  • Athanasios Roumanas
  • Shufeng Zhou

With a PhD in molecular genetics, Elliot Drobetsky is a researcher in biomedical sciences and heads the Genomic Instability Research Unit. For oncology, he serves as assistant to the chief of the Immunology-Oncology Axis at the Centre de recherche de l'Hôpital Maisonneuve-Rosemont. He is also a full professor in the Faculty of Medicine at Université de Montréal.

Research Unit

Genomic Instability

For many years, this research unit has been interested in the cellular response to DNA damage.  Currently, our work focuses on understanding the regulation of nucleotide excision repair (NER) during the S phase of the human cell cycle. We have also developed a new test to study the efficiency of NER as a function of the cell cycle (Auclair et al. 2008 Proc Natl Acad Sci 283:5533-5541). NER is the only pathway in human cells that can remove DNA damage caused by a multitude of environmental carcinogens (e.g., ultraviolet light) as well as by some common chemotherapy drugs (e.g., cisplatin). Our research may therefore have important implications in cancer development and treatment.

  • Bélanger F, Angers JP, Fortier E, Hammond-Martel, I, Costantino, S, Drobetsky EA, Wurtele H (2016) Mutations in replicative stress response pathways are associated with S phase-specific defects in nucleotide excision repair, J Biol Chem, 291:522-537
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  • Vadnais, C, Davoudi, S, Afshin, M, Harada, R, Dudley, R, Clermont, P-L, Drobetsky, EA, and Nepveu, A (2012) CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Res, 40:4483-4495.
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  • Auclair Y, Rouget R, Belisle JM, Costantino S, and Drobetsky EA (2010). Requirement for functional DNA polymerase eta in genome-wide repair of UV-induced DNA damage during S phase. DNA Repair, 9:754–764.
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  • Auclair Y, Rouget R, Affar EB, and Drobetsky EA (2008) ATR kinase is required for global nucleotide excision repair exclusively during S phase in human cells. Proc Natl Acad Sci 105:17896-17901
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  • Mathonnet, G, Léger, C, Desnoyers, J, Drouin, R, Therrien, JP, and Drobetsky, EA (2003). UV wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells. Proc Natl Acad Sci 100:7219-7224.
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  • Therrien, J-P, Drouin, R, Baril, C, and Drobetsky, EA (1999). Human cells compromised for p53 function exhibit defective global- and transcription-coupled–nucleotide excision repair whereas cells compromised for pRb function are defective only in global repair. Proc. Natl. Acad. Sci. 96:15038-043.
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  • Loignon M, Fetni, R, Gordon, AJE, and Drobetsky, EA (1997). A p53-independent pathway for induction of p21waf1cip1 and concomitant G1 arrest in UV-irradiated human skin fibroblasts. Cancer Res. 15: 3390-94.
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  • Sage, E, Lamolet, B, Brulay, E, Moustacchi, E, Chateauneuf, A and Drobetsky, EA (1996). The mutagenic specificity of solar ultraviolet light in nucleotide excision repair-deficient rodent cells. Proc Natl Acad Sci 93:176-180.
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  • Drobetsky, EA,Turcotte, J, and Chateauneuf, A (1995). A role for ultraviolet-A in solar mutagenesis. Proc. Natl. Acad. Sci. 92:2350-2354.
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  • Drobetsky EA, Grosovsky, AJ and Glickman BW (1987) The specificity of UV-induced mutations at an endogenous locus in mammalian cells. Proc Nat. Acad Sci, 84: 9103-9107.
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Education

  • Postdoctoral fellowship

    Institut Curie, Paris

  • PhD in molecular genetics

    York University, Toronto

  • BSc in human genetics

    Université McGill, Montréal

  • BA in political science

    Concordia University, Montreal

Awards

  • 2002 Senior Research Scholar  (FRQS)
  • 2000 Junior 2 Research Scholar  (FRQS)
  • 1995 New Investigator Award  (IRSC)
  • 1990 Postdoctoral fellowship  (Rothschild Foundation)
  • 1990 Postdoctoral fellowship  (CRSNG)