Full professor
Affiliation
Department of Medicine at Université de Montréal
Research Axes
Team
- François Bélanger
- Jean-François Lemay
- Émile Fortier
- Sari Gezzar-Dandashi
- Cassandra Roussel
With a PhD in molecular genetics, Elliot Drobetsky is a researcher in biomedical sciences and heads the Genomic Instability Group at the Centre de recherche de l'Hôpital Maisonneuve-Rosemont. He is full professor in the Department of Medicine at Université de Montréal.
Research Unit
Genomic Instability
For many years, this research unit has been interested in the cellular response to DNA damage. Currently, our work focuses on understanding the regulation of nucleotide excision repair (NER) during S phase of the cell cycle in cultured human cells. NER is the only pathway in humans for removal of DNA damage caused by a multitude of ubiquitous environmental mutagens/carcinogens (e.g., solar ultraviolet light, benzo(a)pyrene) as well as by various chemotherapy drugs (e.g., cisplatin). Our research therefore has important implications for both cancer development and treatment.
Publications
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Lemay JF, St-Hilaire E, Ronato DA, Gao Y, Bélanger F, Gezzar-Dandashi S, Kimenyi Ishimwe AB, Sawchyn C, Lévesque D, McQuaid M, Boisvert F-M, Mallette FA, Masson J-Y, Drobetsky EA*, Wurtele H* (2022). A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response. PLoS Biol, doi: 10.1371/journal.pbio.3001543.
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Bélanger F, Fortier E, Dubé M, Lemay J-F, Buisson R, Masson J-Y, Elsherbiny A, Costantino S, Carmona E, Mes-Masson A-M, Wurtele H, Drobetsky E (2018). Replication protein A availability during DNA replication stress is a major determinant of cisplatin resistance in ovarian cancer cells. Cancer Res, 78:5561-5573.
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Bélanger F, Angers JP, Fortier E, Hammond-Martel, I, Costantino, S, Drobetsky EA, Wurtele H (2016). Mutations in replicative stress response pathways are associated with S phase-specific defects in nucleotide excision repair, J Biol Chem, 291:522-537.
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Bélanger F, Rajotte V, Drobetsky EA (2014). A majority of human melanoma cell lines exhibits an S phase-specific defect in excision of UV-induced DNA photoproducts. PLoS One, doi: 10.1371/journal.pone.0085294.
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Auclair Y, Rouget R, Belisle JM, Costantino S, and Drobetsky EA (2010). Requirement for functional DNA polymerase eta in genome-wide repair of UV-induced DNA damage during S phase. DNA Repair, 9:754–764.
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Auclair Y, Rouget R, Affar EB, and Drobetsky EA (2008). ATR kinase is required for global nucleotide excision repair exclusively during S phase in human cells. Proc Natl Acad Sci 105:17896-17901.
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Drobetsky, EA,Turcotte, J, and Chateauneuf, A (1995). A role for ultraviolet-A in solar mutagenesis. Proc. Natl. Acad. Sci. 92:2350-2354.
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Drobetsky EA, Grosovsky, AJ and Glickman BW (1987) The specificity of UV-induced mutations at an endogenous locus in mammalian cells. Proc Nat. Acad Sci, 84: 9103-9107.
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Education
Postdoctoral fellowship
Institut Curie, Paris
PhD in molecular genetics
York University, Toronto
BSc in human genetics
Université McGill, Montréal
BA in political science
Concordia University, Montreal
Awards
- 2002 Senior Research Scholar (FRQS)
- 2000 Junior 2 Research Scholar (FRQS)
- 1995 New Investigator Award (IRSC)
- 1990 Postdoctoral fellowship (Rothschild Foundation)
- 1990 Postdoctoral fellowship (CRSNG)