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Christopher E. Rudd

Rudd, Christopher E.

Full professor

Affiliation

Université de Montréal

Research Axes

Immunology-oncology

Contact information

Phone: 514-252-3400, poste5878

christopher.e.rudd@umontreal.ca

christopher-rudd-lab-montreal.com

Team

  • Elham Ben Saad
  • Xueyang Guo
  • Mark Issa
  • Alexandra Kazanova
  • Janna Krueger
  • Catherine Ménard
  • Jeidane Saloua
  • François Santinon
  • Thai Hien Tu

Christopher E. Rudd, PhD, is the director of the Cell Signalling in Immunotherapy Research Unit and the chief of the Immunology-Oncology Axis at the Centre de recherche de l'Hôpital Maisonneuve-Rosemont. He is also a professor in the Faculty of Medicine and the Department of Microbiology, Infectious Diseases and Immunology at Université de Montréal.

Christopher E. Rudd's research focuses on signal transduction pathways in T lymphocytes and on how these pathways control immune functions. His unit discovered the CD4 and CD8-p56lck complexes, which are initiators of the phosphorylation and activation cascade in T lymphocytes. His more recent interest lies in the pathways that control T lymphocyte adhesion and T lymphocyte movement in lymph nodes and the mechanisms through which co-receptors such as CD28 and CTLA-4 control immunity. He identified glycogen synthase kinase 3 (GSK-3), a serine/threonine kinase, as a central regulator of programmed cell death-1 (PD-1) expression on T lymphocytes and demonstrated the applicability of GSK-3 small molecule inhibitors in the negative regulation of PD-1 for viral infection clearance. His research is helping to uncover the signalling events that control the adaptive immune response and that aid in the development of therapeutics to treat infection, autoimmunity and cancer.

Research Unit

Cell Signalling in Immunotherapy

Theme

Signalling mechanisms that control the immune function of T lymphocytes and its application in the treatment of cancer and infection.

Research topics

  • Signal transduction in T lymphocytes
  • T-cell adhesion and migration mechanisms
  • Function of co-receptors (CD28, CTLA-4, PD-1) on T lymphocytes
  • Immunotherapy in cancer and infection
  • Taylor, A., Harker, J. A., Chanthong, K., Stevenson, P. G., Zuniga, E. I. and Rudd, C. E. (2016) Glycogen synthase kinase 3 inactivation drives T-bet-mediated downregulation of co-receptor PD-1 to enhance CD8(+) cytolytic T cell responses. Immunity 44, 274-286
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  • Liu, H., Schneider, H., Recino, A., Richardson, C., Goldberg, M. W. and Rudd, C. E. (2015) The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. Molecular Cell 59, 840-849.
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  • Huang, Y. H., Zhu, C., Kondo, Y., Anderson, A. C., Gandhi, A., Russell, A. et al. (2015) CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 517, 386-390.
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  • Camirand, G., Wang, Y., Lu, Y., Wan, Y.Y., Lin, Y., Deng, D, Guz, G., David L. Perkins, D.L., Finn P.W, Farber, D.L., Richard A. Flavell, R., Shlomchik, W.D., Fadi G. Lakkis, F.G. Rudd, C.E. and Rothstein, D. (2014) CD45 ligation increases antigen-mediated expansion of regulatory T cells by promoting interactions with dendritic cells in vivo. J Clin Invest. 124, 4603-13
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  • Wei, B., Han, L., Abbink, T. E., Groppelli, E., Lim, D., Thaker, Y. R., Gao, W., Zhai, R., Wang, J., Lever, A., Jolly, C., Wang, H., and Rudd, C. E. (2013) Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology 10, 101.
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  • Smith, X., Schneider, H., Kohler, K., Liu, H., Lu, Y., and Rudd, C. E. (2013) The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76. Science Signal 6, ra65.
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  • Schneider, H., Downey, J., Smith, A., Zinselmeyer, B. H., Rush, C., Brewer, J. M., Wei, B., Hogg, N., Garside, P., and Rudd, C. E. (2006) Reversal of the TCR stop signal by CTLA-4. Science 313, 1972-1975.
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  • Liu, H., Purbhoo, M. A., Davis, D. M., and Rudd, C. E. (2010) SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering. Proc Natl Acad Sci U S A 107, 10166-10171.
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  • Raab, M., Wang, H., Lu, Y., Smith, X., Wu, Z., Strebhardt, K., Ladbury, J. E., and Rudd, C. E. (2010) T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity 32, 541-556.
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  • Rudd, C. E. (2008) The reverse stop-signal model for CTLA4 function. Nat Rev Immunol 8, 153-160.
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Education

  • Research Fellow in immunology

    Laboratory of Immunobiology, Dana Cancer Institute, Boston

  • Research Fellow in Pathology

    Harvard Medical School

  • PhD

    University of London

  • PhD

    University College, London

  • MSc

    University of Ottawa

  • BSc

    McGill University

Awards

  • 2006 Wellcome Trust Distinction Award  (Wellcome Trust)
  • 2002 Elected Fellow  (Academy of Medical Sciences)
  • 2001 Elected Fellow  (Royal College of Pathologists)
  • 2000 Elected Member  (Royal College of Pathologists)
  • 2000 Principal Research Fellowship  (Wellcome Trust)
  • 1993 Scholar Award  (Leukemia Society of America)
  • 1990 Claudia Adams Barr Research Award, Boston
  • 1988 Family Investigator Award  (Cancer Research Institute/Benjamin Jacobson)
  • 1985 Postdoctoral Fellowship  (Cancer Research Institute, New York)
  • 1980 PhD Fellowship  (Imperial Cancer Research Fund Bursary, London)