Passer au contenu principal

Caroline Lamarche

Lamarche, Caroline

MD MSc

Affiliation

Université de Montréal

Research Axes

Nephrology

Contact information

Phone: 514-252-3400, poste8682

caroline.lamarche.1@umontreal.ca

Caroline Lamarche is a nephrologist and researcher who oversees the Immunotherapy Unit of the Nephrology Axis. Her medical practice focuses on kidney transplantation, and her research work aims to improve patients’ immune tolerance to their transplant while maintaining the effectiveness of their immune system to fight infections and cancers. Her work ranges from basic research in immunology to clinical studies of immunotherapy and cell therapy.

Research Unit

Immunology and cell therapy in transplantation

Regulatory T cells (Tregs) are key cells that mediate transplant tolerance. Our goal is to use their properties to reduce transplant rejection while avoiding the side effects associated with conventional immunosuppressant drugs. We are studying their biology to modulate their efficacy in vivo or in vitro (adoptive immunotherapy). We are also studying the impact of uremia (dialysis) on the biology of Tregs and how this may manifest after transplantation.

  • Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells. Dawson NA*, Lamarche C*, Hoeppli RE, Bergqvist P, Fung VC, McIver E, Huang Q, Gillies J, Speck M, Orban PC, Bush JW, Mojibian M, Levings MK. (* Co-first author)
    More detail
  • Guiding regulatory T cells to the allograft. Lamarche C, Levings MK. Curr Opin Organ Transplant. 2018 Feb;23(1):106-113.
    More detail
  • Clinical-Scale Rapid Autologous BK Virus-Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy. Lamarche C, Orio J, Georges-Tobar V, Pincez T, Goupil M, Dahmani A, Carli C, Brasey A, Busque L, Delisle JS. Transplantation. 2017 Nov;101(11):2713-2721
    More detail
  • Efficacy of Acute Cellular Rejection Treatment According to Banff Score in Kidney Transplant Recipients: A Systematic Review. Lamarche C, Côté JM, Sénécal L, Cardinal H. Transplant Direct. 2016 Nov 15;2(12):e115
    More detail
  • BK Polyomavirus and the Transplanted Kidney: Immunopathology and Therapeutic Approaches. Lamarche C, Orio J, Collette S, Senécal L, Hébert MJ, Renoult É, Tibbles LA, Delisle JS. Transplantation. 2016 Nov;100(11):2276-2287.
    More detail

Education

  • Postdoctorat

    Megan Levings’ lab, BC Children Research Institute, UBC, Vancouver

  • Maîtrise

    Laboratoire de JS Delisle, HMR, Université de Montréal, Montréal.

  • Spécialisation en néphrologie

    Université de Montréal, Collège royal des médecins et chirurgiens du Canada

  • Spécialisation en médecine interne

    Université de Montréal, Collège royal des médecins et chirurgiens du Canada

  • Doctorat en médecine (MD)

    Université de Sherbrooke

Awards

  • 2019 New investigator award  (Faculty of Medicine of Université de Montréal)
  • 2017 CIHR Fellowship
  • 2017 KRESCENT Post-doctoral Fellowship award
  • 2017 Dean’s list  (Université de Montréal)