MD MSc
Affiliation
Université de Montréal
Research Axes
Caroline Lamarche is a nephrologist and researcher who oversees the Immunotherapy Unit of the Nephrology Axis. Her medical practice focuses on kidney transplantation, and her research work aims to improve patients’ immune tolerance to their transplant while maintaining the effectiveness of their immune system to fight infections and cancers. Her work ranges from basic research in immunology to clinical studies of immunotherapy and cell therapy.
Research Unit
Immunology and cell therapy in transplantation
Regulatory T cells (Tregs) are key cells that mediate transplant tolerance. Our goal is to use their properties to reduce transplant rejection while avoiding the side effects associated with conventional immunosuppressant drugs. We are studying their biology to modulate their efficacy in vivo or in vitro (adoptive immunotherapy). We are also studying the impact of uremia (dialysis) on the biology of Tregs and how this may manifest after transplantation.
Publications
Voir toutes les publications-
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells. Dawson NA*, Lamarche C*, Hoeppli RE, Bergqvist P, Fung VC, McIver E, Huang Q, Gillies J, Speck M, Orban PC, Bush JW, Mojibian M, Levings MK. (* Co-first author)
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Guiding regulatory T cells to the allograft. Lamarche C, Levings MK. Curr Opin Organ Transplant. 2018 Feb;23(1):106-113.
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Clinical-Scale Rapid Autologous BK Virus-Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy. Lamarche C, Orio J, Georges-Tobar V, Pincez T, Goupil M, Dahmani A, Carli C, Brasey A, Busque L, Delisle JS. Transplantation. 2017 Nov;101(11):2713-2721
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Efficacy of Acute Cellular Rejection Treatment According to Banff Score in Kidney Transplant Recipients: A Systematic Review. Lamarche C, Côté JM, Sénécal L, Cardinal H. Transplant Direct. 2016 Nov 15;2(12):e115
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BK Polyomavirus and the Transplanted Kidney: Immunopathology and Therapeutic Approaches. Lamarche C, Orio J, Collette S, Senécal L, Hébert MJ, Renoult É, Tibbles LA, Delisle JS. Transplantation. 2016 Nov;100(11):2276-2287.
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Lamarche C, Maltzman JS. The ONE Study: One Small Step for Patient Care, a Giant Leap for Cell Therapy. Am J Kidney Dis. 2021 Feb;77(2):297-299. doi: 10.1053/j.ajkd.2020.07.006. Epub 2020 Aug 5. PMID: 32763258.
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Lamarche C, Iliuta IA, Kitzler T. Infectious Disease Risk in Dialysis Patients: A Transdisciplinary Approach. Can J Kidney Health Dis. 2019 Apr 29;6:2054358119839080. doi: 10.1177/2054358119839080. PMID: 31065378; PMCID: PMC6488776.
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Lamarche C, Levings MK. Guiding regulatory T cells to the allograft. Curr Opin Organ Transplant. 2018 Feb;23(1):106-113. doi: 10.1097/MOT.0000000000000483. PMID: 29140829.
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Lamarche C, Orio J, Georges-Tobar V, Pincez T, Goupil M, Dahmani A, Carli C, Brasey A, Busque L, Delisle JS. Clinical-Scale Rapid Autologous BK Virus- Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy. Transplantation. 2017 Nov;101(11):2713-2721. doi: 10.1097/TP.0000000000001698. PMID: 28230645.
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Lamarche C, Côté JM, Sénécal L, Cardinal H. Efficacy of Acute Cellular Rejection Treatment According to Banff Score in Kidney Transplant Recipients: A Systematic Review. Transplant Direct. 2016 Nov 15;2(12):e115. doi: 10.1097/TXD.0000000000000626. PMID: 27990480; PMCID: PMC5142362.
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Dawson NA, Lamarche C, Hoeppli RE, Bergqvist P, Fung VC, McIver E, Huang Q, Gillies J, Speck M, Orban PC, Bush JW, Mojibian M, Levings MK. Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells. JCI Insight. 2019 Mar 21;4(6):e123672. doi: 10.1172/jci.insight.123672. PMID: 30753169; PMCID: PMC6483008.
Education
Postdoctorat
Megan Levings’ lab, BC Children Research Institute, UBC, Vancouver
Maîtrise
Laboratoire de JS Delisle, HMR, Université de Montréal, Montréal.
Spécialisation en néphrologie
Université de Montréal, Collège royal des médecins et chirurgiens du Canada
Spécialisation en médecine interne
Université de Montréal, Collège royal des médecins et chirurgiens du Canada
Doctorat en médecine (MD)
Université de Sherbrooke
Awards
- 2019 New investigator award (Faculty of Medicine of Université de Montréal)
- 2017 CIHR Fellowship
- 2017 KRESCENT Post-doctoral Fellowship award
- 2017 Dean’s list (Université de Montréal)