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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Jean-Sébastien Delisle

Delisle, Jean-Sébastien

Associate professor

Affiliation

Université de Montréal

Research Axes

Clinical research

Contact information

smartineau.hmr@ssss.gouv.qc.ca

Team

  • Guillaume Bonnaure
  • Cédric Carli
  • Amina Dahmani
  • Simon Del Testa
  • Camille Gagnon
  • Valérie Janelle
  • Shirin Lak
  • Béatrice Portier
  • Caroline Rulleau

Dr. Jean-Sébastien Delisle is a hematologist and researcher who oversees the Cancer Immunology and Transplantation Research Unit. Dr. Delisle divides his time between his lab and his medical practice in hematology and hematopoietic stem cell transplantation/cell therapy. Dr Delisle is also the Medical director of the Centre d’excellence en thérapie cellulaire (CETC) which manufactures therapeutic cell products. His research interests cover the entire spectrum from fundamental research to clinical applications in immunology and immunotherapy. Dr. Delisle is also an associate professor in the Faculty of Medicine at Université de Montréal.

Research Unit

Cancer Immunology and Transplantation

The biology of T lymphocytes

T lymphocytes can have many functions. The signals that dictate the different stages of T lymphocyte differentiation are still poorly understood, and the ability to manipulate these signals for therapeutic purposes is a priority for our laboratory. We focus on the roles of the cytokine TGF-β in memory T cell differentiation as well as the signals leading to T lymphocyte dysfunction in patients, in tumours and in cultures to expand T cells. We also study the factors that determine how other hematopoietic cells modulate T-cell responses.

Adoptive immunotherapy in humans

Our laboratory is interested in the in-vitro expansion and differentiation of human T lymphocytes so that these cells can be used in clinical research protocols. In this area, we have adapted and developed cell culture systems to both increase the therapeutic potential of in-vitro educated T lymphocytes and study the fundamental biology of human T lymphocytes. Two adoptive immunotherapy protocols have been directly derived from the work in our lab and are currently being studied in patients.

  • Lak S, Janelle V, Djedid A, Boudreau G, Brasey A, Lisi V, Smaani A, Carli C, Busque L, Lavallée VP, Delisle JS. Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy. Mol Ther Methods Clin Dev. 2022, 4;27:230-245.
  • Serroukh Y, Hébert J, Busque L, Mercier F, Rudd CE, Assouline S, Lachance S, Delisle JS. Blasts in context : the impact of the immune environment on acute myeloid leukemia prognosis and treatment. Blood Rev. 2022. 19:100991.
  • Martineau, S., Rivest, C., Rahal, A., Marcotte K. (2021). Development of an open-source facial rehabilitation website for severe Bell’s palsy: a within-subject study on user experience and patient’s compliance with the MEPP-website. Disability and Rehabilitation.
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  • Gascon, L. Martineau, S., Saltychev, M., Rahal, A., Moubayed, S. (2021). French Canadian Translation, Cultural Adaptation, and Validation of Facial Clinimetric Evaluation Scale and Facial Disability Index Questionnaires for Patients with Peripheral Facial Paralysis. Facial Plastic Surgery & Aesthetic Medicine.
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  • Martineau, S., Chouinard, A.-M., Piette, E., Rahal, A., Marcotte, K. (2020). The Mirror Effect Plus Protocol for acute Bell’s palsy: A randomized and longitudinal study on facial rehabiliation. Acta Oto-Laryngologica.
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  • Martineau, S., Gascon, L., Rahal, A., Marcotte, K., Moubayed, S. (2020). French Canadian Validation of the SAQ questionnaire. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 1-15.
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  • Martineau, S., Martel-Sauvageau, V., Chouinard, A.-M., Piette, E., Rahal, A., Marcotte, K. (2020). A pilot study on the Mirror Effect PLUS Protocol: A standardized and adapted facial rehabilitation for acute Bell’s Palsy. Revue Canadienne d’Orthophonie et d’Audiologie. Volume 44, no 2, 57-72.
  • Martineau, S., Dufour-Fournier, C., Rahal, A., Marcotte, K. (2018). Rééducation orthophonique post myoplastie d’allongement du temporal (MAT) : Une étude de trois patients. Revue Canadienne d’Orthophonie et d’Audiologie. Volume 42, 2, p. 117-126.
  • Marcotte, K., Sanchez-Gonzalez, E., Arbour, C., Brambati, S.M., Bedetti, C., Martineau, S., Descoteaux M. et Gosselin, N. (2020). Long-term discourse outcomes and their relationship to the arcuate fasciculus in moderate to severe adulthood traumatic brain injury. Brain and Language, Volume 204.
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  • Marcotte, K., Mc Sween, M.-P., Pouliot, M., Martineau, S., Pauzé, A.-M., Wiseman-Hakes C., MacDonald, S., (2017). Normative Study of the Functional Assessment of Verbal Reasoning and Executive Strategies (FAVRES) Test in the French-Canadian population, Journal of Speech, Language and Hearing Research. 60 (8), 2217-2227.

Education

  • Doctor of Medicine

    Université McGill

  • Internal medicine

    Université McGill

  • Fellow in hematology

    Université McGill

  • Clinical fellow in hematopoietic cell grafts

    Université de Montréal

  • PhD

    Université de Montréal

Awards

  • 2019 Career Award  (FRQS)
  • 2017 Career Award  (FRQS)
  • 2017 Professional of the Year  (The Leukemia-lymphoma Society of Canada, Quebec Chapter)
  • 2011 Career Award  (FRQS)
  • 2006 Clinician Scientist Training Award  (IRSC)
  • 2004 FRQS-Secrétariat du sang Award  (FRQS)
  • 1999 Elizabeth Ann Munro Gordon Prize  (Université McGill)
  • 1994 James McGill Entrance Scholarship