Associate professor
Affiliation
Université de Montréal
Research Axes
Contact information
Team
- Guillaume Bonnaure
- Cédric Carli
- Amina Dahmani
- Simon Del Testa
- Camille Gagnon
- Valérie Janelle
- Shirin Lak
- Béatrice Portier
- Caroline Rulleau
Dr. Jean-Sébastien Delisle is a hematologist and researcher who oversees the Cancer Immunology and Transplantation Research Unit. Dr. Delisle divides his time between his lab and his medical practice in hematology and hematopoietic stem cell transplantation/cell therapy. Dr Delisle is also the Medical director of the Centre d’excellence en thérapie cellulaire (CETC) which manufactures therapeutic cell products. His research interests cover the entire spectrum from fundamental research to clinical applications in immunology and immunotherapy. Dr. Delisle is also an associate professor in the Faculty of Medicine at Université de Montréal.
Research Unit
Cancer Immunology and Transplantation
The biology of T lymphocytes
T lymphocytes can have many functions. The signals that dictate the different stages of T lymphocyte differentiation are still poorly understood, and the ability to manipulate these signals for therapeutic purposes is a priority for our laboratory. We focus on the roles of the cytokine TGF-β in memory T cell differentiation as well as the signals leading to T lymphocyte dysfunction in patients, in tumours and in cultures to expand T cells. We also study the factors that determine how other hematopoietic cells modulate T-cell responses.
Adoptive immunotherapy in humans
Our laboratory is interested in the in-vitro expansion and differentiation of human T lymphocytes so that these cells can be used in clinical research protocols. In this area, we have adapted and developed cell culture systems to both increase the therapeutic potential of in-vitro educated T lymphocytes and study the fundamental biology of human T lymphocytes. Two adoptive immunotherapy protocols have been directly derived from the work in our lab and are currently being studied in patients.
Publications
Voir toutes les publications-
Lak S, Janelle V, Djedid A, Boudreau G, Brasey A, Lisi V, Smaani A, Carli C, Busque L, Lavallée VP, Delisle JS. Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy. Mol Ther Methods Clin Dev. 2022, 4;27:230-245.
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Serroukh Y, Hébert J, Busque L, Mercier F, Rudd CE, Assouline S, Lachance S, Delisle JS. Blasts in context : the impact of the immune environment on acute myeloid leukemia prognosis and treatment. Blood Rev. 2022. 19:100991.
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Martineau, S., Rivest, C., Rahal, A., Marcotte K. (2021). Development of an open-source facial rehabilitation website for severe Bell’s palsy: a within-subject study on user experience and patient’s compliance with the MEPP-website. Disability and Rehabilitation.
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Gascon, L. Martineau, S., Saltychev, M., Rahal, A., Moubayed, S. (2021). French Canadian Translation, Cultural Adaptation, and Validation of Facial Clinimetric Evaluation Scale and Facial Disability Index Questionnaires for Patients with Peripheral Facial Paralysis. Facial Plastic Surgery & Aesthetic Medicine.
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Martineau, S., Chouinard, A.-M., Piette, E., Rahal, A., Marcotte, K. (2020). The Mirror Effect Plus Protocol for acute Bell’s palsy: A randomized and longitudinal study on facial rehabiliation. Acta Oto-Laryngologica.
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Martineau, S., Gascon, L., Rahal, A., Marcotte, K., Moubayed, S. (2020). French Canadian Validation of the SAQ questionnaire. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 1-15.
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Martineau, S., Martel-Sauvageau, V., Chouinard, A.-M., Piette, E., Rahal, A., Marcotte, K. (2020). A pilot study on the Mirror Effect PLUS Protocol: A standardized and adapted facial rehabilitation for acute Bell’s Palsy. Revue Canadienne d’Orthophonie et d’Audiologie. Volume 44, no 2, 57-72.
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Martineau, S., Dufour-Fournier, C., Rahal, A., Marcotte, K. (2018). Rééducation orthophonique post myoplastie d’allongement du temporal (MAT) : Une étude de trois patients. Revue Canadienne d’Orthophonie et d’Audiologie. Volume 42, 2, p. 117-126.
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Marcotte, K., Sanchez-Gonzalez, E., Arbour, C., Brambati, S.M., Bedetti, C., Martineau, S., Descoteaux M. et Gosselin, N. (2020). Long-term discourse outcomes and their relationship to the arcuate fasciculus in moderate to severe adulthood traumatic brain injury. Brain and Language, Volume 204.
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Marcotte, K., Mc Sween, M.-P., Pouliot, M., Martineau, S., Pauzé, A.-M., Wiseman-Hakes C., MacDonald, S., (2017). Normative Study of the Functional Assessment of Verbal Reasoning and Executive Strategies (FAVRES) Test in the French-Canadian population, Journal of Speech, Language and Hearing Research. 60 (8), 2217-2227.
Education
Doctor of Medicine
Université McGill
Internal medicine
Université McGill
Fellow in hematology
Université McGill
Clinical fellow in hematopoietic cell grafts
Université de Montréal
PhD
Université de Montréal
Awards
- 2019 Career Award (FRQS)
- 2017 Career Award (FRQS)
- 2017 Professional of the Year (The Leukemia-lymphoma Society of Canada, Quebec Chapter)
- 2011 Career Award (FRQS)
- 2006 Clinician Scientist Training Award (IRSC)
- 2004 FRQS-Secrétariat du sang Award (FRQS)
- 1999 Elizabeth Ann Munro Gordon Prize (Université McGill)
- 1994 James McGill Entrance Scholarship