Investigate the role of lysine methylation in senescence and cancer by studying the JUMONJI family of lysine demethylases.
The regulatory mechanisms of lysine demethylases as well as the biological role of demethylation during different cellular processes including proliferation, transcriptional regulation, the DNA damage response, and tumorigenesis.
Identify new therapeutic targets to treat cancer. To achieve this goal, the laboratory integrates different systems and approaches [in genomics (ChIP-chip, ChIP-seq, RNA-seq and microarray chips), proteomics (MS/MS), cytology (fluorescent microscopy, immunohistochemical markers), and genetics (cell and mouse lines)] to elucidate the role of demethylases in different biological pathways.
Analyze the effects of the deregulated expression of demethylases on heterochromatin formation during oncogene-induced senescence (a tumour suppression mechanism).
Determine the signalling pathways regulated by demethylases and their role in cell transformation.