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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Cellular Immunogenetics

Our goal is to measure the homeostatic significance of different immune system cell populations to identify each one's impact on the predisposition to complex genetic diseases, such as autoimmune diseases and cancer.

Research interests

This unit also studies:

  • Variations in subpopulations of T lymphocytes, natural killer cells and dendritic cells in various mouse lines.
  • The understanding of the dynamics of immune system cell populations.
  • The impact of genetic mutations that cause monogenic diseases, such as lactic acidosis and Li-Fraumeni syndrome, on immune system homeostasis.

These studies will serve as a springboard for translational research to restore immune balance and prevent the onset or slow the progression of various autoimmune diseases and lymphoid cancers. To achieve these goals, we use a variety of technologies: transgenic and congenic mice, cell immunology, multiparameter flow cytometry, and genetic polymorphism analysis.