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Immunologie moléculaire

Immunologie moléculaire

Molecular Immunology

Notre unité étudie la réponse immunitaire et le développement des lymphocytes T in vivo à l’aide de modèles de souris transgéniques et knock-outs. Nous utilisons différentes approches de biologie moléculaire et cellulaire telles que la cytométrie, la transgénèse, l’inactivation de gènes et des analyses transcriptomiques.

Our unit studies the immune response and development of T lymphocytes in vivo using transgenic and knock-out mouse models. We use different molecular and cellular biology approaches such as cytometry, transgenesis, gene inactivation and transcriptome analysis.

Research interests

  • Study of the development of memory T lymphocytes: identification of the cascade of molecular events required for memory T lymphocyte development and survival (CIHR-funded project).
  • Novel approaches to adoptive therapy using resident memory T lymphocytes (CCSRI-funded project).
  • Study of the development of T lymphocytes in the thymus: determination of the role of orphan nuclear receptors in the thymic development of T lymphocytes (NSERC-funded project).
  • Study of the development of monocyte-derived dendritic cells and the identification of their roles in the immune response (CIHR-funded project).