Immunology and cell therapy in transplantation
Regulatory T cells (Tregs) are key cells that mediate transplant tolerance. Our goal is to use their properties to reduce transplant rejection while avoiding the side effects associated with conventional immunosuppressant drugs. We are studying their biology to modulate their efficacy in vivo or in vitro (adoptive immunotherapy). We are also studying the impact of uremia (dialysis) on the biology of Tregs and how this may manifest after transplantation.